Description

1,3-Piperidinedicarboxylic Acid, 5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (3R,5S)-Rel- is a high-purity, stereochemically defined building block of significant importance in advanced organic synthesis. This compound, with CAS number 914260-22-3, is specifically engineered to serve as a critical intermediate in the development of complex pharmaceutical molecules and bioactive compounds. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetic Synthesis: Used to incorporate constrained, functionalized piperidine scaffolds into peptide analogs to enhance metabolic stability and binding affinity.
• Protease Inhibitor Development: Serves as a core structural element in the design and synthesis of novel protease inhibitors.
• Chemical Biology Research: Employed in the creation of specialized molecular probes and tool compounds for studying enzyme function and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Can be utilized in the preparation of chiral ligands for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	1,3-Piperidinedicarboxylic Acid, 5-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (3R,5S)-Rel-
CAS No.	914260-22-3
Molecular Formula	C27H30N2O6
Molecular Weight	478.54 g/mol
Synonyms	(3R,5S)-5-[(tert-Butoxycarbonyl)amino]-1-(9H-fluoren-9-ylmethyl)piperidine-1,3-dicarboxylate; Fmoc-3S,5R-Boc-Amino-Pip(1,3-diAcid)-OMe (common abbreviation); rel-(3R,5S)-1-((9H-Fluoren-9-yl)methyl) 5-((tert-butoxycarbonyl)amino)piperidine-1,3-dicarboxylate; 5-(Boc-amino)-1-Fmoc-piperidine-1,3-dicarboxylic acid; Boc-5-amino-1-Fmoc-piperidine-3-carboxylic acid derivative; Chiral Fmoc/Boc-protected piperidine dicarboxylate; (3R,5S)-1-Fmoc-5-N-Boc-aminopiperidine-1,3-dicarboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are available upon request, providing detailed results for parameters such as assay (HPLC), enantiomeric excess (Chiral HPLC or SFC), and specified impurities. We adhere to cGMP principles for the manufacture of pharmaceutical intermediates where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC/SFC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.