Description

2-Pyrrolidinecarbonitrile, 1-(2-Aminoacetyl)-, Hydrochloride (1:1), (2S)- is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly those with defined stereochemistry, which is critical for biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where precise stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including protease inhibitors and other enzyme-targeted drugs.
• Peptidomimetic Chemistry: Serves as a constrained proline analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to introduce chiral pyrrolidine scaffolds into target molecules.
• Chemical Biology Research: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways and protein interactions.
• Agrochemical Development: Potential intermediate in the synthesis of advanced, chiral crop protection agents with specific modes of action.

Basic Information

Product Name	2-Pyrrolidinecarbonitrile, 1-(2-Aminoacetyl)-, Hydrochloride (1:1), (2S)-
CAS No.	913980-23-1
Molecular Formula	C7H12N3O·HCl
Molecular Weight	191.65 g/mol (Free base: 154.19 g/mol)
Synonyms	(2S)-1-(2-Aminoacetyl)-2-pyrrolidinecarbonitrile hydrochloride; L-Proline, 1-(aminoacetyl)-, nitrile, hydrochloride (1:1); 1-(Aminoacetyl)-L-prolinenitrile hydrochloride; Glycyl-L-prolinenitrile hydrochloride; (S)-1-(2-Aminoacetyl)pyrrolidine-2-carbonitrile hydrochloride; 913980-23-1; (S)-1-Glycyl-2-cyanopyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-Pyrrolidinecarbonitrile, 1-(2-Aminoacetyl)-, Hydrochloride (1:1), (2S)- is manufactured and tested under strict quality management systems to ensure consistency and purity suitable for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.