Description

Dota Di(Tbu)Ester is a high-purity chemical intermediate, specifically a di-tert-butyl ester derivative of the DOTA chelating agent. This compound is critical for the synthesis of advanced radiopharmaceuticals and diagnostic agents, offering superior stability and complexation properties. It is primarily utilized by research institutions and pharmaceutical manufacturers specializing in medical imaging and targeted radiotherapy.

Application

• Radiopharmaceutical Precursor: Key intermediate for synthesizing DOTA-based ligands used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Theragnostic Agent Development: Building block for creating bifunctional chelators that bind therapeutic radioisotopes like Lutetium-177 or Actinium-225 for cancer treatment.
• Contrast Agent Research: Used in the development of next-generation Gadolinium-based contrast agents for Magnetic Resonance Imaging (MRI).
• Chemical Synthesis: Protected ester form of DOTA, facilitating selective conjugation to peptides, antibodies, or other targeting molecules in complex organic syntheses.
• Academic & Industrial R&D: Essential reagent for research in coordination chemistry, metal chelation studies, and the development of novel diagnostic platforms.

Basic Information

Product Name	Dota Di(Tbu)Ester
CAS No.	913542-71-9
Molecular Formula	C26H48N4O8
Molecular Weight	544.68 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,7-bis(1,1-dimethylethyl) ester; DOTA-tris(t-Bu ester); DOTA-di(t-butyl) ester; DOTA-(tBu)2; 2,2',2''-(10-(2-((tert-Butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid tert-butyl ester; DOTA bis-tert-butyl ester; DOTA di-tert-butyl ester; DOTA(tBu)2
EINECS	Contact for details

Quality Control

Our Dota Di(Tbu)Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.