Description

1,4,7,10-Tetraazacyclododecane-1,7-Dicarboxylic Acid, 1,7-Bis(1,1-Dimethylethyl) Ester is a key protected intermediate in the synthesis of sophisticated macrocyclic chelating agents. This compound is critical for the development of high-performance contrast agents used in medical imaging, such as MRI, due to its role in forming stable, inert complexes with gadolinium and other lanthanide ions. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and advanced material scientists working on diagnostic and therapeutic applications.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing macrocyclic gadolinium-based contrast agents (GBCAs) for Magnetic Resonance Imaging (MRI).
• Ligand Synthesis: Serves as a protected precursor for creating DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its derivatives, which are renowned for their high thermodynamic and kinetic stability.
• Radiopharmaceuticals: Used in the development of chelators for radioisotopes (e.g., 68Ga, 177Lu, 90Y) for targeted cancer diagnostics (PET/SPECT) and therapy.
• Catalysis Research: Acts as a ligand scaffold for designing transition metal catalysts in asymmetric synthesis and oxidation reactions.
• Material Science: Employed in the creation of functionalized surfaces, sensors, and luminescent materials utilizing lanthanide ions.
• Academic & Industrial R&D: A valuable reagent for research in coordination chemistry, supramolecular chemistry, and novel chelator design.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,7-Dicarboxylic Acid, 1,7-Bis(1,1-Dimethylethyl) Ester
CAS No.	913542-69-5
Molecular Formula	C22H42N4O4
Molecular Weight	426.60 g/mol
Synonyms	1,7-Di-tert-butyl DOTA ester; 1,7-Di-Boc-DOTA-tris(t-Bu ester); tert-Butyl 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,7-diyldiacetate; 1,7-Bis(tert-butoxycarbonylmethyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane; DOTA-tris(t-Bu ester)-1,7-Boc; Protected DOTA intermediate; 1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid, 1,7-bis(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,7-Dicarboxylic Acid, 1,7-Bis(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to avoid exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.