Description

n-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-2-Amine is a high-value, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, making it a crucial building block for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who are synthesizing novel quinazoline-based molecules for drug discovery and advanced material applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted kinase inhibitors and other bioactive quinazoline derivatives for oncology and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the introduction of the quinazolin-2-amine scaffold into complex molecular architectures.
• Drug Discovery & Medicinal Chemistry: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to develop new drug candidates.
• Agrochemical Research: Intermediate for developing novel herbicides, fungicides, or insecticides with quinazoline cores.
• Material Science: Potential building block for organic electronic materials, such as OLEDs or semiconductors, due to the conjugated quinazoline system.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	n-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-2-Amine
CAS No.	913067-91-1
Molecular Formula	C₁₆H₂₂BN₃O₂
Molecular Weight	299.18 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylquinazolin-2-amine; 2-Amino-N-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline; N-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-quinazolinamine; 6-(Pinacolatoboryl)-N-methylquinazolin-2-amine; 913067-91-1; Quinazolin-2-amine, N-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our n-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-2-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive coupling reactions. All products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.