Description

[2-Amino-2-(4-Fluoro-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound matters as a key chiral precursor in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and psychiatric therapeutics. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for its role in constructing complex molecular architectures with a fluorinated phenyl moiety, enabling precise structure-activity relationship studies.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Neurological Drug Research: Used in the development of compounds targeting serotonin and dopamine receptors for CNS disorders.
• Peptidomimetic Synthesis: Serves as a protected amino acid derivative in the construction of peptide-like molecules.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in enantioselective synthesis.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by providing a versatile fluorinated aromatic scaffold.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for commercial drug production.

Basic Information

Item	Details
Product Name	[2-Amino-2-(4-Fluoro-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester Hydrochloride
CAS No.	912762-88-0
Molecular Formula	C13H19FN2O2·HCl
Molecular Weight	286.76 g/mol
Synonyms	N-Boc-2-Amino-2-(4-fluorophenyl)ethylamine Hydrochloride; tert-Butyl N-[2-Amino-2-(4-fluorophenyl)ethyl]carbamate Hydrochloride; 1-(4-Fluorophenyl)-2-[(tert-butoxycarbonyl)amino]ethanamine Hydrochloride; (R/S)-[2-Amino-2-(4-fluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester hydrochloride; Boc-4-F-Phe-NH2·HCl; N-α-Boc-4-fluoro-L/D-phenylalaninamide Hydrochloride; 2-[(tert-Butoxycarbonyl)amino]-2-(4-fluorophenyl)ethanamine Hydrochloride
EINECS	Contact for details

Quality Control

Our [2-Amino-2-(4-Fluoro-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality commitment aligns with the standards expected for GMP-grade intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (specify enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.