Description

(4-Bromo-3,6-Dimethoxybenzocyclobuten-1-Yl)Methylaminehydrobromide is a high-purity, synthetically valuable organic building block characterized by its unique benzocyclobutene core functionalized with bromine and amine groups. This compound is essential for advanced pharmaceutical research and fine chemical synthesis, serving as a critical precursor for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active compounds and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides, leveraging its reactive bromine and amine sites for structural diversification.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic electronic materials due to the strained benzocyclobutene ring.
• Ligand and Catalyst Development: Employed in organometallic chemistry for the preparation of novel ligands and catalysts used in asymmetric synthesis.
• Chemical Biology Probe: Utilized in bioconjugation and as a building block for creating molecular probes to study biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	(4-Bromo-3,6-Dimethoxybenzocyclobuten-1-Yl)Methylaminehydrobromide
CAS No.	912440-88-1
Molecular Formula	C11H14Br2NO2
Molecular Weight	360.04 g/mol
Synonyms	1-(Aminomethyl)-4-bromo-3,6-dimethoxybenzocyclobutene hydrobromide; 4-Bromo-3,6-dimethoxy-1-(aminomethyl)benzocyclobutene HBr; (4-Bromo-3,6-dimethoxy-1-benzocyclobuten-1-yl)methanamine hydrobromide; BCB-Br-NH2·HBr; Benzocyclobutene derivative, 4-bromo-3,6-dimethoxy-1-(aminomethyl)-, hydrobromide
EINECS	Contact for details

Quality Control

Our (4-Bromo-3,6-Dimethoxybenzocyclobuten-1-Yl)Methylaminehydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical quality attributes are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and prevent decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.