Description

1-Aminomethyl-3,6-Dimethoxybenzocyclobutene Hydrochloride is a high-purity, functionalized benzocyclobutene derivative offered as a hydrochloride salt for enhanced stability and handling. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate the unique strained-ring reactivity of the benzocyclobutene core.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Organic Synthesis Building Block: Used in cross-coupling reactions, cycloadditions, and as a scaffold for constructing polycyclic compounds in medicinal chemistry.
• Agrochemical Research: Intermediate in the development of new herbicides and fungicides with novel modes of action.
• Material Science: Potential monomer or cross-linking agent for the development of specialty polymers and high-performance resins.
• Academic & Industrial R&D: Valuable reagent for methodological studies and exploring new chemical spaces in synthetic chemistry laboratories.

Basic Information

Product Name	1-Aminomethyl-3,6-Dimethoxybenzocyclobutene Hydrochloride
CAS No.	912342-45-1
Molecular Formula	C12H16ClNO2
Molecular Weight	241.71 g/mol
Synonyms	1-(Aminomethyl)-3,6-dimethoxybenzocyclobutene hydrochloride; BCB-NH2·HCl (dimethoxy); 3,6-Dimethoxybenzocyclobutene-1-methanamine hydrochloride; 1-Aminomethyl-3,6-dimethoxy-benzocyclobuten hydrochloride; (3,6-Dimethoxybenzocyclobuten-1-yl)methanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Aminomethyl-3,6-Dimethoxybenzocyclobutene Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support development and commercial projects requiring material that meets GMP-grade standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.