Description

Sodium Aescinate is a purified, standardized extract derived from the horse chestnut seed (*Aesculus hippocastanum*), chemically modified to its sodium salt form for enhanced stability and bioavailability. This compound is valued for its potent venotonic and anti-inflammatory properties, making it a critical active pharmaceutical ingredient (API) for vascular health formulations. It is primarily utilized by pharmaceutical manufacturers and nutraceutical companies in the development of products aimed at treating chronic venous insufficiency, hemorrhoids, and post-operative edema.

Application

• Pharmaceutical API: Core active ingredient in prescription and over-the-counter (OTC) medications for chronic venous disorders.
• Injectable Formulations: Used in parenteral solutions for the rapid reduction of inflammation and swelling in clinical settings.
• Oral Solid Dosage Forms: Incorporated into tablets, capsules, and softgels for systemic venous tone support.
• Topical Preparations: Key component in creams, gels, and ointments for the localized treatment of hemorrhoids, varicose veins, and bruising.
• Nutraceutical & Dietary Supplements: Used in advanced supplement blends targeting circulatory health and capillary integrity.
• Veterinary Pharmaceuticals: Applied in formulations for treating circulatory issues and inflammation in animals.
• Cosmeceutical Research: Investigated for anti-redness and skin-firming properties in cosmetic serums and treatments.

Basic Information

Product Name	Sodium Aescinate
CAS No.	911297-30-8
Molecular Formula	Typically C55H85NaO24 (Representative for aescinate sodium)
Molecular Weight	~1109.2 g/mol (for C55H85NaO24)
Synonyms	Aescin Sodium Salt; Sodium Aescin; Escin Sodium; β-Aescin Sodium Salt; Aesculus hippocastanum extract, sodium salt; Venostasin® (active component); Reparil® (active component); Venoplant® (active component)
EINECS	Contact for details

Quality Control

Our Sodium Aescinate is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards for pharmaceutical use, with specifications typically aligned with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as assay, impurity profile, and microbiological quality to ensure supply reliability and regulatory compliance for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95.0% (on dried basis)
Loss on Drying	≤ 5.0%
Residue on Ignition (Sulfated Ash)	10.0% - 15.0%
Heavy Metals	≤ 20 ppm
Microbiological Control	Meets Ph. Eur. requirements for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.