Description

6-Chloro-4-Ethyl-4-(4-Fluoro-Phenyl)-3-(2,2,2-Trifluoro-Ethyl)-3,4-Dihydro-1H-Quinazolin-2-One is a high-value, complex heterocyclic compound featuring a quinazolinone core with strategically positioned halogen and fluorinated alkyl groups. This molecular architecture makes it a critical advanced pharmaceutical intermediate for the research and development of novel active ingredients. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties of new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes for clinical trial material (CTM) and commercial Active Pharmaceutical Ingredient (API) production.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services for the pharmaceutical industry.
• Library Synthesis: Utilized for creating focused chemical libraries for high-throughput screening (HTS) in drug discovery programs.
• Reference Standard: Acts as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Item	Details
Product Name	6-Chloro-4-Ethyl-4-(4-Fluoro-Phenyl)-3-(2,2,2-Trifluoro-Ethyl)-3,4-Dihydro-1H-Quinazolin-2-One
CAS No.	910484-31-0
Molecular Formula	C19H15ClF4N2O
Molecular Weight	398.78 g/mol
Synonyms	6-Chloro-4-ethyl-4-(4-fluorophenyl)-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one; 6-Chloro-4-ethyl-4-(p-fluorophenyl)-3-(2,2,2-trifluoroethyl)-1,4-dihydro-2H-quinazolin-2-one; 910484-31-0; Quinazolin-2-one, 6-chloro-4-ethyl-4-(4-fluorophenyl)-3-(2,2,2-trifluoroethyl)-3,4-dihydro-; 6-Chloro-4-ethyl-4-(4-fluorophenyl)-3-(trifluoroethyl)-3,4-dihydro-1H-quinazolin-2-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with GMP-grade material upon request, manufactured in compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.