Description

2-Aminomethyl-3-(4-Trifluoromethoxy-Phenyl)-Propionic Acid is a specialized, high-value pharmaceutical intermediate characterized by its unique trifluoromethoxy-phenyl and aminomethyl-propionic acid structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly in the areas of neurology and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting G-protein-coupled receptors (GPCRs).
• Neurological Research: Used in the development of compounds for potential application in neurological conditions, leveraging the trifluoromethoxy group's ability to influence blood-brain barrier penetration.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for constructing peptidomimetics with improved pharmacological profiles.
• Agrochemical Development: Potential intermediate for creating advanced crop protection agents with specific activity.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-Aminomethyl-3-(4-Trifluoromethoxy-Phenyl)-Propionic Acid
CAS No.	910443-94-6
Molecular Formula	C12H14F3NO3
Molecular Weight	277.24 g/mol
Synonyms	2-(Aminomethyl)-3-[4-(trifluoromethoxy)phenyl]propanoic acid; 3-(4-Trifluoromethoxyphenyl)-2-aminomethylpropionic Acid; 2-Aminomethyl-3-(4-trifluoromethoxyphenyl)propionic Acid; 910443-94-6; (4-Trifluoromethoxyphenyl)-2-aminomethylpropionic Acid; 2-Aminomethyl-3-(p-trifluoromethoxyphenyl)propionic Acid; α-(Aminomethyl)-4-(trifluoromethoxy)benzenepropanoic Acid
EINECS	Contact for details

Quality Control

Our 2-Aminomethyl-3-(4-Trifluoromethoxy-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.