Description

tert-Butyl 3-Oxo-6-(Trifluoromethyl)-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and trifluoromethyl-substituted indane structure. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for CNS-targeting therapies.
• Drug Discovery Scaffold: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies due to its unique spirocyclic core and fluorine substitution.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of synthetic routes for potential APIs under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probe: Used in biochemical and pharmacological research to investigate specific biological pathways and protein interactions.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	tert-Butyl 3-Oxo-6-(Trifluoromethyl)-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	910442-62-5
Molecular Formula	C19H22F3NO3
Molecular Weight	369.38 g/mol
Synonyms	1'-Boc-3-oxo-6-(trifluoromethyl)-2,3-dihydrospiro[indene-1,4'-piperidine]; tert-Butyl 3-oxo-6-(trifluoromethyl)-1,2-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate; 6-(Trifluoromethyl)-1,2-dihydrospiro[indene-1,4'-piperidin]-3-one 1'-carboxylic acid tert-butyl ester; Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 2,3-dihydro-3-oxo-6-(trifluoromethyl)-, 1,1-dimethylethyl ester; 910442-62-5; Boc-protected spirocyclic indanone piperidine trifluoromethyl derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Oxo-6-(Trifluoromethyl)-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with the standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.