Description

9,10-Secochola-5,7,10(19),22-Tetraen-24-Ol, 24-Cyclopropyl-1,3-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, (1α,3β,5Z,7E,24S)- (9Ci) is a high-purity, advanced synthetic intermediate featuring a complex seco-steroidal backbone with protective silyl groups. This compound is of significant value for its role in the targeted synthesis of novel vitamin D analogs and other sterol-based bioactive molecules. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents and conducting structure-activity relationship (SAR) studies.

Application

• Key Intermediate in Pharmaceutical Research: Serves as a critical building block for the synthesis of novel vitamin D receptor (VDR) modulators and secosteroid derivatives.
• Probe Compound Development: Used in biochemical research to study sterol signaling pathways and receptor-ligand interactions.
• Process Chemistry & Scale-Up: Employed in route development and optimization for the production of high-value steroidal active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in universities and research institutes for synthetic organic chemistry projects focused on complex natural product analogs.
• Custom Synthesis Starting Material: Provides a versatile, protected scaffold for contract research organizations (CROs) and CDMOs to create bespoke molecules for client projects.

Basic Information

Product Name	9,10-Secochola-5,7,10(19),22-Tetraen-24-Ol, 24-Cyclopropyl-1,3-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, (1α,3β,5Z,7E,24S)- (9Ci)
CAS No.	910133-69-6
Molecular Formula	C36H64O3Si2
Molecular Weight	601.07 g/mol
Synonyms	(1α,3β,5Z,7E,24S)-24-Cyclopropyl-1,3-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10(19),22-tetraen-24-ol; 24-Cyclopropyl-1,3-bis(tert-butyldimethylsilyloxy)-9,10-secochola-5,7,10(19),22-tetraen-24-ol; TBS-protected Cyclopropyl Vitamin D Intermediate; 1,3-Di-O-TBS-24-cyclopropyl-9,10-secocholatriene; Secosteroid TBS Ether; Vitamin D Analog Intermediate 910133-69-6
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality control protocols to ensure identity, purity, and consistency. Our comprehensive analytical suite includes HPLC, NMR, and MS to verify specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as chemical purity and impurity profile to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.