Description

Tetrakis[(S)-(+)-(1-Adamantyl)-(n-Phthalimido)Acetato]Dirhodium(II) Rh2(S-Ptad)4 is a highly specialized chiral dirhodium(II) carboxylate catalyst, distinguished by its adamantyl and phthalimido substituents. This compound matters for its exceptional ability to facilitate highly enantioselective C-H functionalization and cyclopropanation reactions, enabling the synthesis of complex chiral molecules with precise stereocontrol. It is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Asymmetric C-H Amination: A key catalyst for the enantioselective insertion of nitrenes into C-H bonds to construct chiral amines.
• Enantioselective Cyclopropanation: Enables the synthesis of chiral cyclopropane rings, crucial scaffolds in many pharmaceuticals and natural products.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess.
• Methodology Development in Organic Synthesis: A valuable tool for academic and industrial research groups exploring new asymmetric catalytic transformations.
• Agrochemical Research: Applied in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Catalyst Ligand Screening: Serves as a benchmark or component in libraries for screening new chiral catalyst systems.

Basic Information

Product Name	Tetrakis[(S)-(+)-(1-Adamantyl)-(n-Phthalimido)Acetato]Dirhodium(II)
CAS No.	909389-99-7
Molecular Formula	C84H80N4O12Rh2
Molecular Weight	1564.36 g/mol
Synonyms	Rh2(S-PTAD)4; Dirhodium(II) tetrakis[(S)-(-)-1-(1-adamantyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanoate]; Rh2(S-PTAD)4 Catalyst; (S)-Adamantylphthalimidoacetate Dirhodium(II) Dimer; Dirhodium(II) Tetrakis[(S)-1-(1-Adamantyl)-2-(1,3-dioxoisoindolin-2-yl)acetate]; Rh2(S-1-Ad-ptad)4; Chiral Dirhodium Catalyst Rh2(S-PTAD)4
EINECS	Contact for details

Quality Control

Our Tetrakis[(S)-(+)-(1-Adamantyl)-(n-Phthalimido)Acetato]Dirhodium(II) is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C in a cool, dry place. This material is moisture-sensitive and easily oxidized; prolonged exposure to air, light, or ambient humidity should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Dark green to purple crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	12.0 - 14.0 %
Solubility	Soluble in chlorinated solvents (DCM, chloroform), DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.