Description

4-(Cyclopropylethynyl)-2-Methylbenzoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropylethynyl-substituted benzoic acid scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Organic Synthesis Building Block: Used in cross-coupling reactions, Sonogashira couplings, and other catalytic transformations to construct complex molecular frameworks.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of proprietary compound libraries.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.
• Material Science: Investigated as a monomer or additive for creating specialized polymers with tailored properties.

Basic Information

Product Name	4-(Cyclopropylethynyl)-2-Methylbenzoic Acid
CAS No.	908247-44-9
Molecular Formula	C13H12O2
Molecular Weight	200.23 g/mol
Synonyms	2-Methyl-4-(cyclopropylethynyl)benzoic Acid; 4-(Cyclopropylethynyl)-o-toluic Acid; Benzoic acid, 2-methyl-4-(2-cyclopropylethynyl)-; 908247-44-9; 4-(2-Cyclopropylethynyl)-2-methylbenzoic acid
EINECS	Contact for details

Quality Control

Our production of 4-(Cyclopropylethynyl)-2-Methylbenzoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.