Description

(-)-4,5-Bis[(2R,5R)-2,5-Dimethylphospholano]-1,2-Dihydro-1,2-Dimethyl-3,6-Pyridazinedione(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate is a highly specialized, chiral rhodium-based catalyst, specifically a DuPhos-type ligand complex. This compound is critically important for enabling highly enantioselective hydrogenation and other asymmetric transformations in fine chemical synthesis. It is an essential tool for research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral olefins, enamides, and ketones to produce chiral intermediates.
• Pharmaceutical Intermediate Synthesis: Key for manufacturing active pharmaceutical ingredients (APIs) requiring high enantiomeric purity, such as certain amino acid derivatives and β-lactams.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new asymmetric catalytic cycles in organic chemistry.
• Fine Chemical Production: Enables the synthesis of high-value chiral flavors, fragrances, and specialty materials.
• Process Chemistry Optimization: Employed for scaling up enantioselective reactions from laboratory to pilot plant and commercial production.

Basic Information

Item	Details
Product Name	(-)-4,5-Bis[(2R,5R)-2,5-Dimethylphospholano]-1,2-Dihydro-1,2-Dimethyl-3,6-Pyridazinedione(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate
CAS No.	908128-78-9
Molecular Formula	C₂₆H₄₄BF₄N₂O₂P₂Rh
Molecular Weight	656.31 g/mol
Synonyms	(-)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) Tetrafluoroborate; (R,R)-Me-DuPhos Rhodium(I) Tetrafluoroborate Catalyst; [(R,R)-Me-DuPhos)Rh(COD)]BF₄; Rhodium(I) (1,5-Cyclooctadiene)((2R,5R)-2,5-Dimethylphospholano) Complex; Asymmetric Hydrogenation Catalyst Rh-MeDuPhos; DuPhos-Rhodium Catalyst; (R,R)-MeDuPhos-Rh(COD)BF₄
EINECS	Contact for details

Quality Control

Our (-)-4,5-Bis[(2R,5R)-2,5-Dimethylphospholano]-1,2-Dihydro-1,2-Dimethyl-3,6-Pyridazinedione(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to confirm identity, purity, and enantiomeric excess of the ligand framework. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (argon or nitrogen) to maintain stability and catalytic performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red crystalline or amorphous solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	~15.7% (Theoretical)
Solubility	Soluble in dichloromethane, acetone; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.