Description

4,5-Difluoro-Indan-1-Ylamine is a high-purity fluorinated indane derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms, which can dramatically alter the metabolic stability, bioavailability, and binding affinity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoro motif enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty fluorinated polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized as a building block for fluorinated probes and tags in medicinal chemistry and biochemical research.

Basic Information

Product Name	4,5-Difluoro-Indan-1-Ylamine
CAS No.	907973-34-6
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	1-Amino-4,5-difluoroindane; 4,5-Difluoro-1-indanamine; (4,5-Difluoro-2,3-dihydro-1H-inden-1-yl)amine; 4,5-Difluoroindan-1-amine; 1-Indanamine, 4,5-difluoro-; 907973-34-6; 4,5-Difluoro-1H-inden-1-amine
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-Indan-1-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Enantiomer-specific grades available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.