Description

3-Quinolinecarboxylic Acid, 1-[6-Amino-3-Fluoro-5-(3-Hydroxy-1-Azetidinyl)-2-Pyridinyl]-6-Fluoro-1,4-Dihydro-7-(3-Hydroxy-1-Azetidinyl)-4-Oxo-, Ethyl Ester is a complex, high-purity pharmaceutical intermediate of significant interest in modern medicinal chemistry. Its value lies in its sophisticated molecular architecture, featuring multiple fluorine atoms and azetidinyl groups, which are critical motifs for enhancing the potency and pharmacokinetic properties of target drug candidates. This compound is essential for research and development chemists in the pharmaceutical industry, particularly those focused on synthesizing novel antibacterial agents.

Application

• Key Intermediate for Antibacterial Agents: Primarily used in the research and synthesis of novel quinolone and fluoroquinolone-based antibiotics, leveraging its structural complexity for targeted activity.
• Medicinal Chemistry Research: Serves as a critical building block in drug discovery programs for developing new therapeutic entities with improved efficacy against resistant bacterial strains.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for advanced active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: Used in in-vitro studies to investigate bacterial enzyme inhibition mechanisms, such as DNA gyrase and topoisomerase IV.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for clinical trial materials.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-[6-Amino-3-Fluoro-5-(3-Hydroxy-1-Azetidinyl)-2-Pyridinyl]-6-Fluoro-1,4-Dihydro-7-(3-Hydroxy-1-Azetidinyl)-4-Oxo-, Ethyl Ester
CAS No.	906088-98-0
Molecular Formula	C24H24F2N6O5
Molecular Weight	514.48 g/mol
Synonyms	1-(6-Amino-3-fluoro-5-(3-hydroxyazetidin-1-yl)pyridin-2-yl)-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; Ethyl 1-(6-Amino-3-fluoro-5-(3-hydroxy-1-azetidinyl)-2-pyridinyl)-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylate; WCK 771 Ethyl Ester; Levonadifloxacin Alanyl Ester Intermediate; Advanced Fluoroquinolone Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical development. Certificates of Analysis (COA) are provided with each batch, detailing critical parameters such as purity, identity, and impurity profiles. Quality is assured through analytical methods including HPLC, NMR, and Mass Spectrometry, ensuring consistency and traceability for regulatory submissions. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccant use and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.