Description

Fmocnh-Peg3-Ch2Ch2Nh2 Hcl is a specialized, high-purity chemical building block featuring a hydrophilic polyethylene glycol (PEG) spacer and an amine terminus protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is critical for introducing controlled spacing and solubility into complex molecular architectures, enabling precise chemical synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications in peptide synthesis, bioconjugation, and the development of novel drug delivery systems and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a versatile Fmoc-protected linker or spacer to introduce hydrophilic PEG units into peptide sequences, improving solubility and pharmacokinetic properties.
• Bioconjugation and Linker Chemistry: Used to tether active molecules (e.g., drugs, dyes, targeting ligands) to proteins, antibodies, or nanoparticles via its reactive amine group after Fmoc deprotection.
• Drug Delivery System Development: Incorporated into the design of prodrugs, antibody-drug conjugates (ADCs), and polymer-drug conjugates to enhance water solubility and modulate release profiles.
• Diagnostic Probe Synthesis: Acts as a key intermediate in constructing fluorescent or radioactive probes for imaging and diagnostic assays.
• Material Science and Surface Functionalization: Employed to modify surfaces with amine-reactive groups through the PEG spacer, creating biocompatible coatings.
• Chemical Biology Research: A valuable tool for exploring protein-protein interactions and cellular processes by introducing specific, cleavable linkages.

Basic Information

Product Name	Fmocnh-Peg3-Ch2Ch2Nh2 Hcl
CAS No.	906079-91-2
Molecular Formula	C₂₉H₄₀N₂O₇ • HCl
Molecular Weight	565.10 g/mol (Free base: 528.64 g/mol)
Synonyms	Fmoc-NH-PEG3-CH2CH2NH2 • HCl; 2,5,8,11-Tetraoxatetradecan-14-amine, 13-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, hydrochloride; N-(2-Aminoethyl)-N'-(Fmoc)-3,6,9-trioxaundecanediamine hydrochloride; Fmoc-8-amino-3,6-dioxaoctanoic acid hydrazide (related derivative); Fmoc-PEG3-amine hydrochloride; Fmoc-N-amido-PEG3-amine HCl; Amino-PEG3-Fmoc hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Fmocnh-Peg3-Ch2Ch2Nh2 Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our production adheres to cGMP guidelines where applicable, supporting its use in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.