Description

2-(3-tert-Butoxycarbonylamino-Propylamino)-Nicotinic Acid is a high-purity, protected amino acid derivative primarily used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular scaffolds for the development of novel active pharmaceutical ingredients (APIs) and complex biochemical probes. Its primary applications are found in pharmaceutical R&D, particularly in peptide mimetics and medicinal chemistry, where its specific functional groups enable controlled coupling reactions.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates and novel therapeutic agents.
• Peptide & Peptidomimetic Chemistry: Used to introduce protected aminoalkyl side chains for constructing peptide analogs and mimetics with enhanced stability or bioavailability.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Bioconjugation & Linker Chemistry: Employed in the development of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted delivery platforms.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of specialized, non-commercial compounds under cGMP or research-grade conditions.

Basic Information

Product Name	2-(3-tert-Butoxycarbonylamino-Propylamino)-Nicotinic Acid
CAS No.	904816-06-4
Molecular Formula	C14H21N3O4
Molecular Weight	295.34 g/mol
Synonyms	2-[(3-{[(tert-Butoxy)carbonyl]amino}propyl)amino]pyridine-3-carboxylic acid; 2-(3-Boc-amino-propylamino)-nicotinic acid; Nicotinic acid, 2-[(3-[[(1,1-dimethylethoxy)carbonyl]amino]propyl)amino]-; 2-(3-(tert-Butoxycarbonylamino)propylamino)nicotinic acid; Boc-Apn-OH (common abbreviation); 2-(3-Boc-aminopropylamino)nicotinic acid; 3-Pyridinecarboxylic acid, 2-[[3-[[(1,1-dimethylethoxy)carbonyl]amino]propyl]amino]-
EINECS	Contact for details

Quality Control

Our 2-(3-tert-Butoxycarbonylamino-Propylamino)-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting research and development specifications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.