Description

(S)-1-Amino-2,3-Dihydro-1H-Indene-5-Carbonitrile Hydrochloride is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical research and development. Its value lies in its enantiomerically pure indane core structure, which is a privileged scaffold for designing potent and selective bioactive molecules. This compound is essential for medicinal chemists and process development scientists working in the synthesis of novel therapeutics, particularly in central nervous system (CNS) and cardiovascular drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core building block in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in enantioselective catalytic processes to create complex chiral molecules.
• Protease Inhibitor Development: The indane-5-carbonitrile motif is relevant in the design of inhibitors for enzymes like DPP-4 and other proteases.
• Chemical Biology Probes: Can be utilized to develop tool compounds and molecular probes for investigating biological mechanisms.
• Process Chemistry & Scale-Up: Employed in the development of robust, scalable synthetic routes for pilot plant and commercial manufacturing.

Basic Information

Product Name	(S)-1-Amino-2,3-Dihydro-1H-Indene-5-Carbonitrile Hydrochloride
CAS No.	903557-34-6
Molecular Formula	C10H11N2·HCl
Molecular Weight	194.67 (Free base) / 231.09 (Hydrochloride salt)
Synonyms	(S)-1-Amino-2,3-dihydro-1H-indene-5-carbonitrile HCl; (S)-5-Cyano-2,3-dihydro-1H-inden-1-amine hydrochloride; (1S)-2,3-Dihydro-1H-indene-5-carbonitrile, 1-amino-, hydrochloride; (S)-Indane-5-carbonitrile, 1-amino-, hydrochloride; (S)-1-Aminoindane-5-carbonitrile hydrochloride; (S)-5-Cyano-1-aminoindane hydrochloride; (S)-1-Amino-5-cyanoindane HCl
EINECS	Contact for details

Quality Control

Our (S)-1-Amino-2,3-Dihydro-1H-Indene-5-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. We provide detailed Certificates of Analysis (COA) with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (Anhydrous basis)
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Any individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.