Description

1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine is a specialized organic building block featuring a nitrobenzenesulfonyl protecting group and a pyrrolidine-amine scaffold. This compound is of significant value in pharmaceutical research and development, particularly in the synthesis of complex molecules and active pharmaceutical ingredients (APIs). It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Peptidomimetic Chemistry: Used to introduce constrained pyrrolidine scaffolds into peptide analogs to enhance metabolic stability and bioavailability.
• Protecting Group Strategy: The 2-nitrobenzenesulfonyl (Nosyl) group serves as a versatile amine protecting group in multi-step organic synthesis.
• Library Synthesis: Employed in combinatorial and parallel synthesis for generating diverse chemical libraries for high-throughput screening.
• Agrochemical Research: Acts as a precursor in the development of new herbicides and fungicides with novel modes of action.
• Chemical Biology Probes: Useful for creating molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine
CAS No.	902797-82-4
Molecular Formula	C10H13N3O4S
Molecular Weight	271.29 g/mol
Synonyms	3-Amino-1-[(2-nitrophenyl)sulfonyl]pyrrolidine; 1-(2-Nitrobenzenesulfonyl)-3-aminopyrrolidine; Pyrrolidin-3-amine, 1-[(2-nitrophenyl)sulfonyl]-; 1-Nosyl-3-aminopyrrolidine; 3-Amino-1-(2-nitrobenzenesulfonyl)pyrrolidine; 1-(2-Nitro-phenylsulfonyl)-pyrrolidin-3-ylamine; N-(2-Nitrobenzenesulfonyl)-3-aminopyrrolidine
EINECS	Contact for details

Quality Control

Our 1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, the container should be amber-colored or kept in secondary opaque packaging. For long-term storage, consider maintaining the material under an inert atmosphere to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.