Description

(2,2-Dimethyl-1,3-Dioxolan-4-Yl)Methyl 4-Methylbenzenesulfonate is a high-value chemical intermediate, specifically a protected glycerol derivative activated with a tosylate leaving group. This compound is critical for the controlled synthesis of complex molecules, enabling precise chemical modifications in advanced manufacturing processes. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and specialty chemical sectors for the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for nucleoside analogs, antiviral drugs, and other bioactive molecules requiring stereospecific glycerol backbones.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators where the introduction of a functionalized glycerol moiety is required.
• Polymer & Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, resins, and functional materials with tailored properties.
• Glycochemistry & Carbohydrate Research: Essential for the preparation of glycosyl donors, phospholipid analogs, and other complex sugar derivatives in academic and industrial research.
• Process Chemistry & Scale-up: Employed in pilot plants and commercial production for the efficient, multi-step synthesis of target compounds under controlled conditions.
• Fine Chemical Manufacturing: Acts as a versatile reagent for introducing protected diol functionalities in custom synthesis and contract manufacturing projects.

Basic Information

Product Name	(2,2-Dimethyl-1,3-Dioxolan-4-Yl)Methyl 4-Methylbenzenesulfonate
CAS No.	23737-51-1
Molecular Formula	C13H18O5S
Molecular Weight	286.34 g/mol
Synonyms	(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl p-toluenesulfonate; 1,2-O-Isopropylidene-3-O-tosyl-sn-glycerol; (4R)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl 4-methylbenzenesulfonate; (R)-(-)-1,2-Isopropylidene-3-tosylglycerol; (R)-1,2-O-Isopropylidene-3-O-tosylglycerol; Tosylate of (R)-(-)-1,2-Isopropylidene glycerol; (R)-Tosyl glycidol acetonide; 3-O-Tosyl-1,2-O-isopropylidene-sn-glycerol
EINECS	Contact for details

Quality Control

Our (2,2-Dimethyl-1,3-Dioxolan-4-Yl)Methyl 4-Methylbenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. Certificates of Analysis (COA) are provided, detailing parameters such as assay, enantiomeric excess, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and decomposition. Store away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (R-isomer typical)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.