Description

Ethyl 8-Chloro-1-Cyclopropyl-6,7-Difluoro-1,4-Dihydroquinolone-4-Oxo-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the fluoroquinolone carboxylic acid ester class. This compound is critical for the synthesis of next-generation antibacterial agents, offering a key structural framework for developing potent and broad-spectrum antibiotics. It is primarily sought by research institutions and manufacturers in the pharmaceutical industry engaged in the development and production of novel anti-infective drugs.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a crucial building block in the multi-step synthesis of advanced fluoroquinolone antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new antibacterial candidates with improved efficacy.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the commercial-scale manufacturing processes of specific, potent fluoroquinolone-based APIs.
• Process Chemistry & Scale-Up: Utilized for optimizing synthetic routes and scaling up production from laboratory to pilot plant and full manufacturing scales.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Ethyl 8-Chloro-1-Cyclopropyl-6,7-Difluoro-1,4-Dihydroquinolone-4-Oxo-3-Carboxylate
CAS No.	99696-21-6
Molecular Formula	C₁₅H₁₂ClF₂NO₄
Molecular Weight	343.71 g/mol
Synonyms	Ethyl 8-chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate; 8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester; Ethyl 8-Chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate; Intermediate for Sitafloxacin; Sitafloxacin Intermediate; DU-6859a Intermediate; Fluoroquinolone Carboxylic Acid Ester Intermediate; 1-Cyclopropyl-6,7-difluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 8-Chloro-1-Cyclopropyl-6,7-Difluoro-1,4-Dihydroquinolone-4-Oxo-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.