Description

Methoxypolyethoxylated Cholesterol is a non-ionic surfactant and emulsifier derived from cholesterol, modified with a methoxy-terminated poly(ethylene oxide) chain. This chemical modification imparts valuable amphiphilic properties, making it a crucial functional ingredient for stabilizing complex formulations. It is primarily utilized in the pharmaceutical, cosmetic, and advanced material sectors where biocompatibility and precise interfacial activity are required. This product, identified by CAS NO 99559-58-7, offers a versatile building block for researchers and formulators developing targeted delivery systems and high-performance emulsions.

Application

• As a key stabilizer and emulsifier in the production of lipid nanoparticles (LNPs) for mRNA and siRNA delivery.
• Formulation of cosmetic creams and lotions, particularly in anti-aging and moisturizing products requiring stable oil-in-water emulsions.
• Component in biocompatible coatings for medical devices and implants to enhance surface properties.
• Used in research and development of novel drug delivery vehicles, including liposomes and niosomes.
• As a surfactant and dispersing agent in specialty chemical and material science applications.
• Potential use in diagnostic assays and biosensor development where membrane-mimicking surfaces are needed.

Basic Information

Product Name	Methoxypolyethoxylated Cholesterol
CAS No.	99559-58-7
Molecular Formula	Typically C~33~H~60~O~n~ (n varies with ethoxylation degree)
Molecular Weight	Variable, dependent on the number of ethylene oxide units. Contact for details.
Synonyms	Poly(oxy-1,2-ethanediyl), α-methoxy-ω-hydroxy-, ether with cholesterol; Cholesterol, ethoxylated, methyl ether; PEGylated Cholesterol Methyl Ether; mPEG-Cholesterol; Cholesterol-PEG-OMe; Polyethylene glycol monomethyl ether cholesterol ether; Nonionic cholesterol surfactant
EINECS	Contact for details

Quality Control

Our Methoxypolyethoxylated Cholesterol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a Certificate of Analysis (COA) detailing key parameters such as degree of ethoxylation, purity, and residual solvents. Our quality commitment aligns with cGMP principles where applicable, supporting its use in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white waxy solid or paste
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Degree of Ethoxylation (n, avg.)	As per customer grade (e.g., n=5, 10, 25)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.