Description

3-Hydroxy-7,8-Dihydro-7,8-Dihydroxybenzo(A)Pyrene is a key intermediate metabolite of the polycyclic aromatic hydrocarbon Benzo(a)pyrene, a compound of significant toxicological and environmental interest. Its precise chemical structure makes it an essential reference standard and research material for studying metabolic activation pathways, DNA adduct formation, and carcinogenic mechanisms. This high-purity compound is primarily required by toxicology research laboratories, environmental testing facilities, and pharmaceutical development teams focused on molecular toxicology and biomarker discovery.

Application

• Toxicological Research: Used as a critical metabolite standard in studies investigating the metabolic activation and detoxification pathways of Benzo(a)pyrene.
• Biomarker Analysis: Serves as a reference compound for the development and validation of analytical methods (e.g., HPLC-MS, GC-MS) to detect and quantify DNA adducts and other biomarkers of exposure.
• Environmental Monitoring: Employed in calibrating equipment and validating assays that assess human and ecological exposure to polycyclic aromatic hydrocarbon (PAH) pollution.
• Carcinogenicity Studies: Essential for mechanistic research into the role of specific dihydrodiol metabolites in the initiation of chemical carcinogenesis.
• Pharmaceutical R&D: Used in early-stage drug discovery to screen for compounds that may inhibit specific metabolic enzymes (e.g., cytochrome P450) involved in procarcinogen activation.
• Regulatory & Forensic Science: Acts as a certified reference material for laboratories conducting compliance testing or forensic analysis related to PAH contamination.

Basic Information

Product Name	3-Hydroxy-7,8-Dihydro-7,8-Dihydroxybenzo(A)Pyrene
CAS No.	99346-47-1
Molecular Formula	C20H14O3
Molecular Weight	302.33 g/mol
Synonyms	3-Hydroxy-7,8-dihydro-7,8-dihydroxybenzo[a]pyrene; 3-Hydroxy-BaP-7,8-dihydrodiol; 3-OH-BaP-7,8-diol; Benzo[a]pyrene-3-hydroxy-7,8-dihydrodiol; 7,8-Dihydro-7,8-dihydroxy-3-hydroxybenzo[a]pyrene; 3-Hydroxy-BP-7,8-diol; BaP-3-ol-7,8-dihydrodiol
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-7,8-Dihydro-7,8-Dihydroxybenzo(A)Pyrene is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. For long-term stability, the material should be kept in a desiccated environment. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Solubility	Soluble in DMSO, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.