Description

8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 99295-33-7. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel central nervous system (CNS) active agents. It is primarily sought by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the development of new therapeutic entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel benzazepine-based drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize pharmacological profiles of new chemical entities.
• Preclinical Development: Serves as a critical starting material for producing gram to kilogram quantities of lead compounds for toxicology and pharmacokinetic studies.
• Reference Standard: Utilized as an analytical standard for method development and quality control in API (Active Pharmaceutical Ingredient) manufacturing.
• Chemical Biology Probes: Acts as a scaffold for developing tool compounds to study specific biological pathways and receptor interactions.

Basic Information

Product Name	8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
CAS No.	99295-33-7
Molecular Formula	C17H19Br2NO
Molecular Weight	413.15 g/mol
Synonyms	8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol HBr; 8-Bromo-7-hydroxy-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; SKF-83566 hydrobromide; 1H-3-Benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, hydrobromide; 8-Br-7-OH-3-Me-5-Ph-THBA HBr
EINECS	Contact for details

Quality Control

Our 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.