Description

Sialic Acid, [4-14C] is a carbon-14 radiolabeled derivative of the essential monosaccharide N-acetylneuraminic acid, a key component of glycoproteins and glycolipids. This labeled compound is critical for conducting precise metabolic and pharmacokinetic tracer studies, enabling researchers to track the incorporation, distribution, and turnover of sialic acid in biological systems. It is an indispensable tool for scientists in pharmaceutical R&D, biochemistry, and glycobiology who require high-specific-activity tracers for advanced analytical techniques like LC-MS and autoradiography.

Application

• Metabolic Pathway Tracing: Used to study the biosynthesis, degradation, and salvage pathways of sialic acid in cell cultures and animal models.
• Glycoconjugate Research: Essential for labeling and tracking the assembly of sialylated glycoproteins and gangliosides.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in ADME studies to trace the fate of sialic acid-containing drug candidates or biologics.
• Enzyme Activity Assays: Serves as a substrate for radiometric assays of sialidases (neuraminidases) and sialyltransferases.
• Diagnostic Probe Development: Used in the research and development of radiolabeled probes for imaging sialic acid expression, which is often altered in cancers and infections.
• Host-Pathogen Interaction Studies: Applied to investigate how pathogens utilize or modify host sialic acids, relevant to influenza and other microbial research.

Basic Information

Product Name	Sialic Acid, [4-14C]
CAS No.	99217-80-8
Molecular Formula	C11H1914CNO9 *
Molecular Weight	~309.3 g/mol (for unlabeled form)*
Synonyms	N-Acetylneuraminic Acid, [4-14C]
Neu5Ac, [4-14C]
5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic Acid, [4-14C]
Carbon-14 Labeled Sialic Acid
[4-14C]-Sialic Acid
14C-Sialic Acid
Radiolabeled N-Acetylneuraminic Acid
EINECS	Contact for details

* Formula and weight are for the unlabeled compound. Specific activity and exact molecular weight depend on the radiochemical concentration and are provided on the Certificate of Analysis.

Quality Control

Every batch of Sialic Acid, [4-14C] is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and specific activity suitable for sensitive biological research. Quality is verified by techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is supplied with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Our production adheres to GLP principles to guarantee batch-to-batch consistency and data integrity for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store frozen (≤ -20°C) or as specified on the label or Certificate of Analysis. This product is hygroscopic (moisture-sensitive). Allow the vial to reach ambient temperature before opening to minimize moisture ingress. For long-term storage, keep the primary container within a secondary sealed container. Store in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC)	Conforms to reference standard
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) [Typical]
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Water, Ethanol, or as specified
Concentration	As per customer requirement (µCi/mL or mCi/mmol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.