Description

2-(4-Aminophenyl)Cyclopropanecarboxylic Acid is a specialized organic compound featuring a cyclopropane ring fused to an aromatic amine-substituted carboxylic acid, making it a valuable chiral building block and intermediate in advanced synthesis. Its unique structure provides a rigid, three-dimensional scaffold that is highly sought after for constructing complex molecules with specific stereochemical and pharmacological properties. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, structurally defined intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the cyclopropane moiety contributes to biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Investigated as a monomer or additive for producing polymers with unique thermal and mechanical properties due to its strained ring system.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up processes under cGMP guidelines.

Basic Information

Product Name	2-(4-Aminophenyl)Cyclopropanecarboxylic Acid
CAS No.	99060-12-5
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	2-(4-Aminophenyl)cyclopropanecarboxylic acid; 4-(1-Carboxycyclopropyl)aniline; 2-(p-Aminophenyl)cyclopropanecarboxylic acid; 1-(4-Aminophenyl)cyclopropane-1-carboxylic acid; (1R,2S)-rel-2-(4-Aminophenyl)cyclopropanecarboxylic acid (for stereoisomer); 4-(Cyclopropanecarbonyl)aniline derivative; 99060-12-5; p-Aminophenylcyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Aminophenyl)Cyclopropanecarboxylic Acid is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. Our quality commitment supports applications requiring material for GLP research, process development, and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Optical Purity (Chiral HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.