Description

4-Chloro-6-Fluoro-3-Nitro-Quinoline is a high-value, multi-functional heterocyclic building block distinguished by its unique halogen and nitro substitution pattern. This compound matters for its critical role as a versatile synthetic intermediate in the development of advanced pharmaceutical and agrochemical agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, particularly for antimicrobial, anticancer, and kinase inhibitor applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its halogenated quinoline core.
• Material Science Research: Serves as a building block for creating organic electronic materials, dyes, and photoactive compounds.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-Chloro-6-Fluoro-3-Nitro-Quinoline
CAS No.	99010-07-8
Molecular Formula	C9H4ClFN2O2
Molecular Weight	226.59 g/mol
Synonyms	4-Chloro-6-fluoro-3-nitroquinoline; 3-Nitro-4-chloro-6-fluoroquinoline; Quinoline, 4-chloro-6-fluoro-3-nitro-; 99010-07-8; 4-Chloro-6-fluoro-3-nitro-quinoline; 6-Fluoro-4-chloro-3-nitroquinoline; 4-Chloro-6-fluoroquinoline-3-nitro
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Fluoro-3-Nitro-Quinoline is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be performed under subdued lighting or in amber glass containers when possible.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.