Description

(2Rs,3Rs)-3-(2-Ethoxyphenoxy)-2-Methanesulfonyloxy-1-(4-Nitrobenzoyloxy)-3-Phenylpropane CAS NO 98854-88-7 is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring multiple functional groups, makes it a valuable building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for creating targeted molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the multi-step synthesis of complex drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial production of APIs, where its defined stereochemistry ensures batch-to-batch consistency.
• Medicinal Chemistry Research: Serves as a key precursor for constructing molecular libraries in drug discovery programs aimed at identifying new lead compounds.
• Asymmetric Synthesis: Employed in reactions requiring high stereoselectivity due to its fixed (2R,3R) configuration, enabling the construction of other complex chiral molecules.
• Reference Standard: Can be utilized as an analytical standard for method development and quality control in the production of related pharmaceutical compounds.

Basic Information

Product Name	(2Rs,3Rs)-3-(2-Ethoxyphenoxy)-2-Methanesulfonyloxy-1-(4-Nitrobenzoyloxy)-3-Phenylpropane
CAS No.	98854-88-7
Molecular Formula	C25H25NO9S
Molecular Weight	515.54 g/mol
Synonyms	(2R,3R)-3-(2-Ethoxyphenoxy)-2-(methanesulfonyloxy)-1-[(4-nitrophenyl)carbonyloxy]-3-phenylpropane; 1-(4-Nitrobenzoyloxy)-2-methanesulfonyloxy-3-(2-ethoxyphenoxy)-3-phenylpropane, (2R,3R)-; (2R,3R)-1-[(4-Nitrobenzoyl)oxy]-2-[(methylsulfonyl)oxy]-3-(2-ethoxyphenoxy)-3-phenylpropane; (2R,3R)-3-(2-Ethoxyphenoxy)-2-(methylsulfonyloxy)-1-(4-nitrobenzoyloxy)propylbenzene; 98854-88-7; Propane, 3-(2-ethoxyphenoxy)-2-[(methylsulfonyl)oxy]-1-[(4-nitrophenyl)carbonyloxy]-3-phenyl-, (2R,3R)-
EINECS	Contact for details

Quality Control

Our (2Rs,3Rs)-3-(2-Ethoxyphenoxy)-2-Methanesulfonyloxy-1-(4-Nitrobenzoyloxy)-3-Phenylpropane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,3R)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.