Description

(R)-(+)-4-(2-Chlorophenyl)-2-Hydroxy-5,5-Dimethyl-1,3,2-Dioxaphosphorinane 2-Oxide is a high-value chiral organophosphorus compound that serves as a critical intermediate in asymmetric synthesis. Its primary commercial value lies in its role as a precursor for the synthesis of novel chiral phosphine ligands and catalysts, which are essential for producing enantiomerically pure pharmaceuticals and fine chemicals. This compound is particularly sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing new catalytic processes and active ingredients.

Application

• Chiral Ligand Synthesis: A key building block for the preparation of novel P-chiral phosphine and phosphinite ligands used in asymmetric hydrogenation and cross-coupling reactions.
• Pharmaceutical Intermediate: Employed in the research and development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Catalyst Development: Serves as a precursor for homogeneous transition metal catalysts that require precise stereochemical control.
• Agrochemical Research: Used in the synthesis of chiral pesticides and herbicides where specific stereochemistry is required for biological activity and environmental safety.
• Material Science: Investigated for the creation of chiral organophosphorus polymers and advanced functional materials with specific optical properties.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic synthesis and process optimization within R&D laboratories.

Basic Information

Product Name	(R)-(+)-4-(2-Chlorophenyl)-2-Hydroxy-5,5-Dimethyl-1,3,2-Dioxaphosphorinane 2-Oxide
CAS No.	98674-87-4
Molecular Formula	C11H14ClO4P
Molecular Weight	276.65 g/mol
Synonyms	(R)-(+)-2-Chloro-α,α-dimethylbenzenemethanol cyclic methylphosphonate; (R)-4-(2-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide; (R)-(+)-2-Hydroxy-5,5-dimethyl-4-(2-chlorophenyl)-1,3,2-dioxaphosphorinane 2-oxide; P-Chiral dioxaphosphorinane oxide; Chiral cyclic methylphosphonate; (R)-Methylphosphonic acid cyclic ester with 2-chloro-α,α-dimethylbenzyl alcohol
EINECS	Contact for details

Quality Control

Every batch of (R)-(+)-4-(2-Chlorophenyl)-2-Hydroxy-5,5-Dimethyl-1,3,2-Dioxaphosphorinane 2-Oxide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. Our quality system is designed to support cGMP and ISO standards for advanced chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing chiral purity (by chiral HPLC), chemical purity (by HPLC), specific rotation, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Specific Rotation [α]D20	+20.0° to +25.0° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.