Description

(S)-(+)-5,5-Dimethyl-2-Hydroxy 4-Phenyl-1,3,2-Dioxaphos-Phorinane-2-Oxide is a high-purity, chiral organophosphorus compound of significant interest in advanced synthetic chemistry. Its primary value lies in its role as a versatile chiral auxiliary or ligand for asymmetric synthesis, enabling the production of enantiomerically pure intermediates. This product is essential for research and development laboratories and production facilities in the pharmaceutical and fine chemical sectors, where precise stereochemical control is critical.

Application

• Asymmetric Catalysis: Employed as a chiral ligand in transition metal-catalyzed reactions, such as hydrogenation or cross-coupling, to induce high enantioselectivity.
• Pharmaceutical Intermediate Synthesis: A key building block for the development of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Chiral Auxiliary: Used to temporarily introduce chirality into a molecule during multi-step synthetic sequences, directing the stereochemical outcome of subsequent reactions.
• Methodology Development: Serves as a standard or reagent in academic and industrial research for developing new asymmetric synthetic protocols.
• Fine Chemical Production: Integral to the manufacture of specialty chemicals, agrochemicals, and flavors & fragrances where enantiopurity impacts product performance.

Basic Information

Product Name	(S)-(+)-5,5-Dimethyl-2-Hydroxy 4-Phenyl-1,3,2-Dioxaphos-Phorinane-2-Oxide
CAS No.	98674-81-8
Molecular Formula	C₁₃H₁₉O₄P
Molecular Weight	270.26 g/mol
Synonyms	(S)-(+)-5,5-Dimethyl-4-phenyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide; (S)-5,5-Dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide; (S)-DMP; (S)-DMPO; (S)-Dimethylphenyl dioxaphosphorinane oxide; (S)-Phenyl-DMPO; (S)-ATPH; (S)-α,α-Dimethyl-β-hydroxybenzylphosphonic acid cyclic methyl ester
EINECS	Contact for details

Quality Control

Our production of (S)-(+)-5,5-Dimethyl-2-Hydroxy 4-Phenyl-1,3,2-Dioxaphos-Phorinane-2-Oxide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.