Description

Bis-(Aminoxy)-Peg3 is a heterobifunctional polyethylene glycol (PEG) derivative featuring reactive aminoxy groups at both termini. This compound is a critical building block in bioconjugation and materials science, enabling the stable, site-specific crosslinking of biomolecules and polymers under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors for developing next-generation therapeutics and functionalized surfaces.

Application

• Bioconjugation Linker: For the stable oxime ligation of aldehydes or ketones to create antibody-drug conjugates (ADCs), peptide/protein-polymer hybrids, and labeled biomolecules.
• Hydrogel Formation: Serves as a crosslinking agent for creating biocompatible PEG-based hydrogels used in tissue engineering, 3D cell culture, and drug delivery systems.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and chromatographic media with reactive handles for further coupling of ligands, dyes, or proteins.
• Polymer Chemistry: Acts as a macroinitiator or chain extender in the synthesis of functionalized block copolymers with tailored properties.
• Diagnostic Reagent Synthesis: Employed in the development of immunoassay components and contrast agents by linking targeting moieties to reporter molecules.

Basic Information

Product Name	Bis-(Aminoxy)-Peg3
CAS No.	98627-70-4
Molecular Formula	C12H28N2O6
Molecular Weight	296.36 g/mol
Synonyms	1,11-Bis(aminoxy)-3,6,9-trioxaundecane; α,ω-Bis(O-amino) PEG3; O,O'-Bis(aminopropyl) triethylene glycol; 3,6,9-Trioxaundecane-1,11-diamine, N,N'-dihydroxy-; PEG3 bis(aminoxy); Bis-aminoxy PEG3; Bis(3-aminopropoxy) triethylene glycol; Heterobifunctional PEG, aminoxy-PEG3-aminoxy
EINECS	Contact for details

Quality Control

Our Bis-(Aminoxy)-Peg3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially oxidizable nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by titration)
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.