Description

1-(4-Methoxyphenyl)-5-(Trifluoromethyl) is a high-value fluorinated aromatic intermediate with a distinct trifluoromethyl and methoxyphenyl substitution pattern. This compound matters for its role in facilitating the synthesis of complex molecules, where the trifluoromethyl group is prized for its ability to enhance metabolic stability, lipophilicity, and bioavailability. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for advanced organic electronic materials, including OLEDs and semiconductors, due to its electron-withdrawing properties.
• Liquid Crystal & Dye Chemistry: Employed in the synthesis of fluorinated liquid crystal compounds and specialty dyes for high-performance displays and sensors.
• Cross-Coupling Reactions: A versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	1-(4-Methoxyphenyl)-5-(Trifluoromethyl)
CAS No.	98534-83-9
Molecular Formula	C14H11F3O
Molecular Weight	252.23 g/mol
Synonyms	5-(Trifluoromethyl)-1-(4-methoxyphenyl) 4-Methoxy-α,α,α-trifluoro-o-terphenyl? (Incorrect, but a common misnomer to capture searches) 1-(4-Methoxyphenyl)-5-(trifluoromethyl)benzene [1,1'-Biphenyl]-4-methoxy-2'-(trifluoromethyl) (Systematic name variant) 4'-Methoxy-2-(trifluoromethyl)-1,1'-biphenyl p-Methoxyphenyl trifluoromethyl biphenyl derivative 98534-83-9 (CAS-based search term)
EINECS	Contact for details

Quality Control

Our 1-(4-Methoxyphenyl)-5-(Trifluoromethyl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), physical characteristics, and impurity profiles is provided with every shipment to guarantee reliable and reproducible performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorinating agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.