Description

4-Bromo-7-Chloroquinoline is a versatile halogenated quinoline derivative, a crucial building block in advanced organic synthesis. Its value lies in its dual functionalization, which allows for selective cross-coupling reactions and further derivatization, making it indispensable for creating complex molecular architectures. This high-purity intermediate is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel quinoline-based drug candidates, particularly for antimalarial, anticancer, and antimicrobial applications.
• Agrochemical Synthesis: Used in the research and development of new-generation fungicides and herbicides where the quinoline scaffold provides bioactive properties.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized nitrogen-containing ligands used in transition metal catalysis.
• Material Science Research: Employed in the development of organic semiconductors, light-emitting diodes (OLEDs), and other electronic materials due to the quinoline core's electron-transport characteristics.
• Chemical Biology Probes: Utilized to build fluorescent tags or molecular probes for studying biological processes.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	4-Bromo-7-Chloroquinoline
CAS No.	98519-65-4
Molecular Formula	C9H5BrClN
Molecular Weight	242.50 g/mol
Synonyms	7-Chloro-4-bromoquinoline; 4-Bromo-7-chloroquinoline; Quinoline, 4-bromo-7-chloro-; 98519-65-4; 4-Br-7-Cl-quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-7-Chloroquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.