Description

p-Isopropylcalix[4]arene is a synthetically engineered macrocyclic compound belonging to the calixarene family, characterized by a basket-shaped molecular structure with four phenolic units bridged by methylene groups and substituted with isopropyl groups at the para positions. This unique three-dimensional architecture provides a pre-organized cavity, making it a highly effective host molecule for selective molecular recognition and binding of various guest species, including metal ions and organic molecules. It is a critical building block and research chemical for scientists and engineers in the fields of supramolecular chemistry, sensor development, catalysis, and advanced material science, where precise molecular interaction is paramount.

Application

• Supramolecular Chemistry & Host-Guest Systems: Serves as a foundational scaffold for constructing molecular receptors, capsules, and switches due to its well-defined cavity and modifiable upper and lower rims.
• Chemical Sensors & Detection: Used as a selective binding agent or coating in sensor platforms for the detection of specific ions, gases, or organic compounds.
• Catalysis & Enzyme Mimics: Functionalized derivatives act as nanoreactors or catalysts, mimicking enzyme active sites for specialized organic transformations.
• Separation Science: Employed in the development of novel stationary phases for chromatography or extraction materials for selective separation of isomers or target analytes.
• Advanced Materials: Incorporated into polymers, membranes, and surface coatings to impart specific molecular recognition properties, such as in smart materials or drug delivery systems.
• Pharmaceutical Research: Investigated for potential applications in drug delivery, as a carrier for active pharmaceutical ingredients (APIs), or in the synthesis of complex biomimetic structures.
• Academic & Industrial R&D: A key reagent for fundamental research in nanotechnology, molecular engineering, and the development of new functional materials.

Basic Information

Product Name	p-Isopropylcalix[4]arene
CAS No.	97998-55-5
Molecular Formula	C44H56O4
Molecular Weight	648.92 g/mol
Synonyms	5,11,17,23-Tetraisopropyl-25,26,27,28-tetrahydroxycalix[4]arene; 25,26,27,28-Tetrahydroxycalix[4]arene-5,11,17,23-tetrayl tetraisopropyl; p-tert-Butylcalix[4]arene analog; Isopropylcalixarene; Calix[4]arene tetra-p-isopropyl; Host molecule p-iPrC[4]; 5,11,17,23-Tetra-iso-propylcalix[4]arene
EINECS	Contact for details

Quality Control

Our p-Isopropylcalix[4]arene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR (¹H and ¹³C) for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from prolonged exposure and to prevent contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.