Description

n-Acetylglucosaminyl-β-1-3-Galactosyl-1-4-(n-Acetylglucosaminyl)-1-3-Galactosyl-1-4-Glucosyl-1-Ceramide is a complex glycosphingolipid, specifically a pentasaccharide-ceramide, that serves as a crucial structural and functional component in biological membranes. This compound is of significant interest for its role as a precursor and intermediate in the biosynthesis of more complex gangliosides and other bioactive glycolipids. It is primarily utilized by researchers and manufacturers in the fields of glycobiology, pharmaceutical development, and diagnostic reagent production, where precise molecular structures are required for studying cell signaling, adhesion, and as standards for analytical purposes.

Application

• Biochemical Research: Used as a high-purity standard and intermediate in glycobiology studies to investigate glycosphingolipid metabolism, cell membrane structure, and carbohydrate-protein interactions.
• Pharmaceutical Reference Standard: Serves as a critical quality control standard in the development and analysis of biopharmaceuticals, especially those targeting glycolipid-related pathways.
• Diagnostic Reagent Manufacturing: Employed in the synthesis of components for diagnostic kits and assays designed to detect specific antibodies or enzymes related to glycolipid storage diseases.
• Enzymology Studies: Acts as a specific substrate for glycosyltransferases and glycosidases to study enzyme kinetics, inhibition, and mechanism of action.
• Neuroscience Research: Utilized in research focused on ganglioside biosynthesis and their role in neural development, function, and neurodegenerative disorders.
• Cell Biology & Immunology: Applied in studies exploring the role of glycosphingolipids in cell recognition, immune response modulation, and pathogen-host interactions.

Basic Information

Product Name	n-Acetylglucosaminyl-β-1-3-Galactosyl-1-4-(n-Acetylglucosaminyl)-1-3-Galactosyl-1-4-Glucosyl-1-Ceramide
CAS No.	97666-64-3
Molecular Formula	C73H127N3O33
Molecular Weight	1550.80 g/mol
Synonyms	Gg4-Cer; IV4GalNAcβ,III4GlcNAcβ-GgOse4Cer; Asialo-GM2; GA2 (ambiguous); GalNAcβ1-4(GlcNAcβ1-3)Galβ1-4Glcβ1-1'Cer; N-Acetyl-β-D-galactosaminyl-(1→4)-[N-acetyl-β-D-glucosaminyl-(1→3)]-D-galactosyl-(1→4)-D-glucosyl-(1↔1)-ceramide; Pentasaccharide-ceramide (GlcNAcβ1-3Galβ1-4Glcβ1-1Cer core with GalNAcβ1-4 branch); β-D-GalNAc-(1->4)-[β-D-GlcNAc-(1->3)]-D-Gal-(1->4)-D-Glc-(1<->1)-Cer
EINECS	Contact for details

Quality Control

Our n-Acetylglucosaminyl-β-1-3-Galactosyl-1-4-(n-Acetylglucosaminyl)-1-3-Galactosyl-1-4-Glucosyl-1-Ceramide is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for structural confirmation, and NMR for identity verification, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; partially soluble in Chloroform/Methanol mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.