Description

4-[[(6-Aminohexyl)Amino]Carbonyl]Benzoic Acid is a bifunctional organic compound featuring both a carboxylic acid and a primary amine group, separated by a hexyl spacer, making it a valuable heterobifunctional linker. This molecular architecture is critical for creating stable amide bonds, facilitating the conjugation of biomolecules, polymers, and surfaces in advanced material science. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and diagnostics sectors for developing targeted drug delivery systems, biosensors, and functionalized nanomaterials.

Application

• Bioconjugation and Cross-linking Agent: For covalently linking peptides, proteins, or antibodies to other molecules, particles, or solid supports via its amine and carboxyl reactive sites.
• Pharmaceutical Intermediate: In the synthesis of targeted prodrugs and antibody-drug conjugates (ADCs) where a cleavable or stable linker is required.
• Polymer Functionalization: To introduce reactive amine or carboxyl groups onto polymer backbones for creating smart hydrogels or surface-modifiable materials.
• Diagnostic Assay Development: For immobilizing capture molecules (e.g., antigens, oligonucleotides) onto microplates or sensor chips in ELISA and other immunoassay formats.
• Nanomaterial Surface Modification: To functionalize quantum dots, gold nanoparticles, or magnetic beads for biomedical imaging and therapeutic applications.
• Solid-Phase Synthesis Support: As a building block or linker molecule in the automated synthesis of peptide libraries and other combinatorial chemistry platforms.

Basic Information

Product Name	4-[[(6-Aminohexyl)Amino]Carbonyl]Benzoic Acid
CAS No.	97392-67-1
Molecular Formula	C14H20N2O3
Molecular Weight	264.32 g/mol
Synonyms	4-[(6-Aminohexyl)carbamoyl]benzoic Acid; 4-Carboxy-N-(6-aminohexyl)benzamide; 6-(4-Carboxybenzamido)hexylamine; 4-[(6-Aminohexyl)aminocarbonyl]benzoic Acid; p-[(6-Aminohexyl)carbamoyl]benzoic Acid; 4-Carboxybenzoic Acid N-(6-Aminohexyl)amide; Heterobifunctional Linker 97392-67-1; Amino-PEG6-acid analog (structural)
EINECS	Contact for details

Quality Control

Our 4-[[(6-Aminohexyl)Amino]Carbonyl]Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets high-purity research and production standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.