Description

Boc-L-Valine Thioamide is a protected amino acid derivative where the valine side chain is functionalized as a thioamide. This compound is a critical building block in organic synthesis and peptide chemistry, valued for its role in introducing specific structural motifs and enabling complex molecular transformations. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide-based drugs, and advanced chemical probes.

Application

• Peptide Synthesis Intermediate: Serves as a key precursor for the incorporation of modified valine residues or thioamide bonds into peptide backbones, which can alter stability and biological activity.
• Pharmaceutical Research: Used in the discovery and development of protease inhibitors, receptor ligands, and other bioactive molecules where the thioamide group modulates pharmacokinetic properties.
• Organocatalyst & Ligand Preparation: Acts as a starting material for synthesizing chiral catalysts or ligands used in asymmetric synthesis.
• Chemical Biology Probes: Employed to create labeled or tagged peptides for studying protein-protein interactions, enzyme mechanisms, and cellular processes.
• Material Science Research: Investigated for the development of novel polymers or supramolecular assemblies with unique properties derived from thioamide functionalities.

Basic Information

Product Name	Boc-L-Valine Thioamide
CAS No.	96929-02-1
Molecular Formula	C₁₀H₂₀N₂O₂S
Molecular Weight	232.34 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-methylbutanethioamide; N-(tert-Butoxycarbonyl)-L-valinethioamide; Boc-Val-NH-thio; Boc-L-Valine thioamide; tert-Butyloxycarbonyl-L-valine thioamide; N-Boc-L-valine thioamide; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, thioamide; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanethioamide
EINECS	Contact for details

Quality Control

Our Boc-L-Valine Thioamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.