Description

n-Boc-3-Amino-6-Nitropyridine CAS NO 96721-84-5 is a high-purity, protected heterocyclic amine building block of significant importance in modern organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical, agrochemical, and advanced material industries who require reliable, high-quality intermediates for lead optimization and scale-up.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that utilize pyridine-based structures.
• Material Science Research: Serves as a precursor for creating functionalized ligands, dyes, and photoactive materials due to its nitro and protected amine groups.
• Peptidomimetics & Bioconjugation: The Boc-protected amine is a crucial handle for introducing the pyridine moiety into peptide backbones or for bioconjugation strategies in probe development.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create more complex biaryl structures.
• Chemical Library Production: Employed in combinatorial and parallel synthesis within high-throughput screening libraries for drug discovery programs.

Basic Information

Product Name	n-Boc-3-Amino-6-Nitropyridine
CAS No.	96721-84-5
Molecular Formula	C10H13N3O4
Molecular Weight	239.23 g/mol
Synonyms	tert-Butyl (6-nitro-3-pyridinyl)carbamate; 3-[(tert-Butoxycarbonyl)amino]-6-nitropyridine; 6-Nitro-3-pyridinamine, N-BOC-protected; N-Boc-3-amino-6-nitropyridine; 1,1-Dimethylethyl N-(6-nitro-3-pyridinyl)carbamate; Boc-3-Amino-6-Nitropyridine; (6-Nitro-pyridin-3-yl)-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-3-Amino-6-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability, consistency, and reliability for your critical synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.