Description

Spiro[1H-Indene-1,4'-Piperidine], 2,3-Dihydro-, Hydrochloride is a high-purity, complex organic salt that serves as a critical building block in advanced chemical synthesis. This compound is valued for its unique spirocyclic structure, which provides a rigid three-dimensional framework essential for developing novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for use in drug discovery, process development, and the synthesis of complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Agrochemical Synthesis: Used in the creation of advanced crop protection agents and pesticides that require specific stereochemistry.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and performance materials.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	Spiro[1H-Indene-1,4'-Piperidine], 2,3-Dihydro-, Hydrochloride
CAS No.	96651-85-3
Molecular Formula	C14H18ClN
Molecular Weight	235.75 g/mol
Synonyms	2,3-Dihydrospiro[1H-indene-1,4'-piperidine] hydrochloride; Dihydrospiro[indene-1,4'-piperidine] HCl; Spiro[indane-1,4'-piperidine] hydrochloride; 1',2',3',4'-Tetrahydrospiro[indene-1,4'-pyridine] hydrochloride; 96651-85-3; UNII-9J8F1106FU; 9J8F1106FU; AS-81200; SCHEMBL2180645; Spirocyclic piperidine hydrochloride derivative
EINECS	Contact for details

Quality Control

Our Spiro[1H-Indene-1,4'-Piperidine], 2,3-Dihydro-, Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the exacting standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.