Description

1,2:3,5-Di-o-Isopropylidene-α-D-Apiose CAS NO 94943-41-6 is a high-purity, protected monosaccharide derivative, specifically a diacetonide of the rare sugar D-apiose. This compound serves as a critical chiral building block and advanced intermediate in synthetic organic chemistry, enabling the controlled synthesis of complex carbohydrate structures and nucleoside analogs. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in the development of novel therapeutics, diagnostic probes, and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel nucleoside analogs and antiviral/antitumor drug candidates.
• Glycochemistry Research: Protected sugar donor for constructing complex oligosaccharides, glycoconjugates, and glycomimetics.
• Chemical Biology Probes: Building block for labeling reagents, metabolic probes, and tools to study carbohydrate-protein interactions.
• Fine Chemical Synthesis: Advanced intermediate for producing specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Process Development: Enables route scouting, method development, and scale-up studies in carbohydrate chemistry.

Basic Information

Product Name	1,2:3,5-Di-o-Isopropylidene-α-D-Apiose
CAS No.	94943-41-6
Molecular Formula	C11H18O5
Molecular Weight	230.26 g/mol
Synonyms	D-Apiose 1,2:3,5-Di-O-isopropylidene Acetal; α-D-Apiofuranose 1,2:3,5-Di-O-isopropylidene; 1,2:3,5-Di-O-Isopropylidene-α-D-apiofuranose; Di-O-isopropylidene-D-apiose; 1,2-O-Isopropylidene-3,5-O-isopropylidene-α-D-apiofuranose; (3aR,5R,6S,6aR)-5-(Hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-6-ol
EINECS	Contact for details

Quality Control

Our 1,2:3,5-Di-o-Isopropylidene-α-D-Apiose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.