Description

H-Nle-Nh2 Hcl is a high-purity, protected amino acid derivative, specifically the hydrochloride salt of N-α-Boc-Norleucine amide. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains with the non-natural amino acid norleucine. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and fine chemical synthesis who require reliable, high-quality intermediates for producing novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of norleucine into custom peptide sequences.
• Pharmaceutical Research: Used in the discovery and development of peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation & Labeling: Serves as a precursor for creating modified peptides with specific functional handles for conjugation with drugs, dyes, or biomarkers.
• Structure-Activity Relationship (SAR) Studies: Employed to study the effect of hydrophobic side chain modifications (norleucine substitution) on peptide bioactivity and stability.
• Academic & Industrial R&D: A fundamental reagent in chemistry and biochemistry laboratories for exploring novel peptide structures and functions.
• Production of Reference Standards: Used in the synthesis of high-purity peptide standards for analytical method development and quality control.

Basic Information

Product Name	H-Nle-Nh2 Hcl
CAS No.	94787-97-0
Molecular Formula	C11H23ClN2O3
Molecular Weight	266.76 g/mol
Synonyms	N-α-Boc-Norleucine amide hydrochloride; Boc-Nle-NH2·HCl; (2S)-2-[(tert-Butoxycarbonyl)amino]hexanamide hydrochloride; tert-Butyl (1-amino-1-oxohexan-2-yl)carbamate hydrochloride; Boc-L-Norleucinamide hydrochloride; N-Boc-L-Norleucine amide hydrochloride; Boc-Nle-NH2 hydrochloride; Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-, amide, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our H-Nle-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.