Description

1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxoq is a high-purity, advanced pharmaceutical intermediate belonging to the quinolone class of compounds. Its precise molecular structure makes it a critical building block for the synthesis of next-generation antibacterial agents, where its trifluoromethyl and cyclopropyl groups are key to enhancing drug potency and spectrum. This compound is essential for research and development laboratories, as well as manufacturing facilities, in the global pharmaceutical and fine chemical industries.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a core precursor in the synthesis of potent antibacterial drugs like garenoxacin and other third/fourth-generation fluoroquinolones.
• Pharmaceutical R&D: Used in medicinal chemistry for the research and development of new antimicrobial agents targeting resistant bacterial strains.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production for commercial pharmaceutical manufacturing.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in drug development pipelines.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for specialized chemical entities.

Basic Information

Product Name	1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxoq
CAS No.	94695-52-0
Molecular Formula	C₁₂H₉F₃N₂O₂
Molecular Weight	270.21 g/mol
Synonyms	1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid; 6,7,8-Trifluoro-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; Garenoxacin Intermediate; DW-224a; Q-35 Intermediate; 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxoq is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.