Description

1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinoline Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. Its core value lies in its role as a critical building block in the synthesis of modern fluoroquinolone antibiotics, enabling the development of potent antimicrobial agents. This compound is essential for pharmaceutical R&D laboratories and manufacturers focused on producing next-generation antibacterial drugs to address global health challenges.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a fundamental precursor in the synthesis of potent third and fourth-generation quinolone antimicrobial agents.
• Pharmaceutical Research & Development: Utilized in medicinal chemistry for the discovery and optimization of new antibacterial compounds with improved efficacy and safety profiles.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in scaled-up production processes for final antibiotic drug substances under controlled GMP environments.
• Chemical Synthesis Studies: Used in academic and industrial research to explore novel synthetic pathways and structure-activity relationships (SAR) within the quinolone class.

Basic Information

Product Name	1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinoline Carboxylic Acid Ethyl Ester
CAS No.	94242-51-0
Molecular Formula	C15H13F3NO3
Molecular Weight	312.26 g/mol
Synonyms	Ethyl 1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolincarboxylate; 1-Cyclopropyl-6,7,8-Trifluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Ethyl Ester; 6,7,8-Trifluoro-1-Cyclopropyl-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester; Quinolone Carboxylic Acid Ester Intermediate; Fluoroquinolone Intermediate E94242-51-0; 3-Quinolinecarboxylic Acid, 1,4-dihydro-1-cyclopropyl-6,7,8-trifluoro-4-oxo-, ethyl ester
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinoline Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet stringent internal specifications. Certificates of Analysis (COA) documenting identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.