Description

2(1H)-Quinolinone, 8-Hydroxy-5-[(1R,2R)-1-Hydroxy-2-[(1-Methylethyl)Amino]Butyl]-, Rel- is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its specific stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly in cardiovascular and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and scale-up production of new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to introduce specific chiral centers into target molecules.
• Biochemical Research: Used as a reference standard or ligand in biochemical assays and pharmacological studies.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of other specialized, high-value organic compounds.

Basic Information

Product Name	2(1H)-Quinolinone, 8-Hydroxy-5-[(1R,2R)-1-Hydroxy-2-[(1-Methylethyl)Amino]Butyl]-, Rel-
CAS No.	94198-40-0
Molecular Formula	C16H22N2O3
Molecular Weight	290.36 g/mol
Synonyms	Rel-8-Hydroxy-5-[(1R,2R)-1-hydroxy-2-(isopropylamino)butyl]quinolin-2(1H)-one; (R,R)-Formoterol Impurity; Formoterol Related Compound A; 5-[(1R,2R)-2-[(2-Propan-2-yl)amino]-1-hydroxybutyl]-8-hydroxy-1H-quinolin-2-one; Arformoterol Intermediate; (R,R)-Arformoterol Precursor; 8-Hydroxy-5-[(1R,2R)-1-hydroxy-2-(isopropylamino)butyl]-2(1H)-quinolinone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral chromatography, and NMR spectroscopy. A Certificate of Analysis (COA) detailing identity, purity, chiral purity, and residual solvent levels is provided with each shipment. We support compliance with ICH guidelines and cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R,R isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.