Description

(4S-Trans)-2-Ethyl-2-Methyl-1,3-Dioxolane-4,5-Dimethanol is a high-purity chiral building block and specialty solvent with significant utility in advanced organic synthesis. Its value lies in its unique dioxolane-protected diol structure, which provides both stereochemical control and functional group versatility for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise intermediates for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral and cardiovascular drug candidates.
• Asymmetric Catalyst Ligand Precursor: Used to construct chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Polymer & Resin Modifier: Serves as a monomer or cross-linking agent to introduce hydroxyl functionality and rigidity into specialty polymers and coatings.
• Agrochemical Synthesis: Employed as a building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Solvent for Specialty Reactions: Acts as a polar aprotic solvent for sensitive reactions where moisture control and specific solvation properties are critical.
• Flavor & Fragrance Chemistry: Used in the synthesis of complex, naturally-derived odorants and flavoring agents.

Basic Information

Item	Detail
Product Name	(4S-Trans)-2-Ethyl-2-Methyl-1,3-Dioxolane-4,5-Dimethanol
CAS No.	94134-59-5
Molecular Formula	C9H18O4
Molecular Weight	190.24 g/mol
Synonyms	(4S,5S)-2-Ethyl-2-methyl-1,3-dioxolane-4,5-dimethanol; (4S-trans)-4,5-Bis(hydroxymethyl)-2-ethyl-2-methyl-1,3-dioxolane; (4S,5S)-4,5-Bis(hydroxymethyl)-2-ethyl-2-methyl-1,3-dioxolane; trans-2-Ethyl-2-methyl-4,5-bis(hydroxymethyl)-1,3-dioxolane; (4S,5S)-Dihydroxy-2-ethyl-2-methyl-1,3-dioxolane-4,5-dimethanol; Ethylmethyl dioxolane dimethanol (trans isomer); Chiral dioxolane diol derivative
EINECS	Contact for details

Quality Control

Every batch of (4S-Trans)-2-Ethyl-2-Methyl-1,3-Dioxolane-4,5-Dimethanol undergoes rigorous analytical testing to ensure high chemical purity, enantiomeric excess, and batch-to-batch consistency. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/GC), chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.