Description

(Trans)-1-Benzoyl-4-Phenyl-L-Proline is a high-purity, non-natural amino acid derivative featuring a rigid proline scaffold with aromatic substituents. This compound is valued for its role as a key chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other biologically active compounds.
• Peptidomimetics & Constrained Peptide Design: Used to introduce conformational constraints and aromatic interactions into peptide backbones, enhancing metabolic stability and binding affinity in drug discovery.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalytic reactions to produce enantiomerically pure compounds.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and plant growth regulators that require specific stereochemistry.
• Academic & Institutional Research: A valuable tool for studying enzyme mechanisms, molecular recognition, and structure-activity relationships (SAR) in medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale GMP batches for clinical trials.

Basic Information

Product Name	(Trans)-1-Benzoyl-4-Phenyl-L-Proline
CAS No.	94005-34-2
Molecular Formula	C18H17NO3
Molecular Weight	295.33 g/mol
Synonyms	(2S,4R)-1-Benzoyl-4-phenylpyrrolidine-2-carboxylic acid; (4R)-1-Benzoyl-4-phenyl-L-proline; trans-1-Benzoyl-4-phenyl-L-proline; L-Proline, 1-benzoyl-4-phenyl-, (trans)-; 4-Phenyl-1-benzoyl-L-proline; (2S,4R)-1-Benzoyl-4-phenyl-2-pyrrolidinecarboxylic acid; 94005-34-2; Bz-Phe-Pro-OH (configuration specific)
EINECS	Contact for details

Quality Control

Our (Trans)-1-Benzoyl-4-Phenyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (diastereomeric excess)
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.