Description

1-o-(3-Amino-2-Hydroxypropyl)-D-Glucitol Hydrochloride is a high-purity, functionalized sugar alcohol derivative of significant interest in advanced chemical synthesis. This compound serves as a versatile chiral building block and intermediate, prized for its amino and hydroxyl functional groups which enable selective modifications. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, biotechnology, and specialty chemical sectors for developing novel active ingredients, prodrugs, and sophisticated molecular conjugates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in oncology and metabolic disease research.
• Bioconjugation & Linker Chemistry: Used in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic agents due to its reactive amine handle.
• Carbohydrate Chemistry Research: Serves as a fundamental substrate for studying glycosylation reactions and synthesizing complex oligosaccharide mimics.
• Prodrug Synthesis: Employed to create water-soluble prodrug forms of hydrophobic active pharmaceutical ingredients (APIs) to enhance bioavailability.
• Biomaterial Functionalization: Used to introduce hydrophilic and bioactive moieties onto polymer backbones for hydrogel and tissue engineering applications.
• Diagnostic Reagent Development: Acts as a component in the formulation of contrast agents or fluorescent probes for medical imaging.

Basic Information

Product Name	1-o-(3-Amino-2-Hydroxypropyl)-D-Glucitol Hydrochloride
CAS No.	93963-67-8
Molecular Formula	C9H20ClNO7
Molecular Weight	289.71 g/mol
Synonyms	1-O-(3-Amino-2-hydroxypropyl)-D-glucitol HCl; 1-O-(3-Amino-2-hydroxypropyl)glucitol hydrochloride; 3-Amino-2-hydroxypropyl 1-deoxy-1-(D-glucitol-1-yl) ether hydrochloride; D-Glucitol, 1-O-(3-amino-2-hydroxypropyl)-, hydrochloride; Amino-deoxy-hydroxypropyl glucitol HCl; Glucitol, 1-O-(3-amino-2-hydroxypropyl)-, hydrochloride; (2R)-1-[(2R,3R,4R,5R)-1,2,3,4,5,6-Hexahydroxyhexan-1-yl]oxy-3-amino-2-hydroxypropane hydrochloride
EINECS	Contact for details

Quality Control

Our 1-o-(3-Amino-2-Hydroxypropyl)-D-Glucitol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The container should be sealed immediately after use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.